May 18, 2024

Combination Antibody Therapy Shows Promise in Treating Advanced Cancer Patients

A recent study published in Cancer showcased the potential of a combination antibody therapy in treating individuals with advanced cancer. The trial, which focused on two antibody-based medications targeting the immune system, demonstrated encouraging safety data and anti-tumor activity in participants with various types of advanced cancer.

The two medications tested in the trial, CS1002 and CS1003, work by supporting immune responses against tumor cells. CS1002 enhances the activation and proliferation of T immune cells by binding to a T cell receptor known as CTLA-4. On the other hand, CS1003, also referred to as nofazinlimab, blocks the programmed cell death protein 1, which is expressed on different types of immune cells and is involved in suppressing the immune system.

The clinical trial, conducted at nine study sites in Australia and China from April 26, 2018, to January 18, 2022, consisted of three parts: phase Ia, which involved monotherapy dose-escalation; phase Ib, focusing on combination therapy dose escalation; and phase III, which included expansion. The trial enrolled a total of 92 patients with advanced/metastatic solid, relapsed, or refractory tumors.

Throughout the trial, researchers did not observe any dose-limiting toxicities or reach a maximum tolerated dose. Common treatment-related side effects such as diarrhea, fatigue, and rash were reported among the participants. While serious side effects like intestinal inflammation and severe skin reactions were experienced by some patients, the overall safety profile of the combination therapy was deemed manageable.

Out of the 61 evaluable patients, approximately 37.7% showed a positive response to the treatment. Notably, higher response rates were noted with specific dosing regimens of CS1002, particularly in certain cancers like melanoma and skin cancer.

The investigators concluded that the combination of CS1002 and CS1003 demonstrated promising anti-tumor activities and had a manageable safety profile across different dosing levels. This suggests that further exploration of this combination therapy for the treatment of solid tumors is warranted.

In summary, the study provides valuable insights into the potential of antibody-based combination therapy in treating advanced cancer patients and underscores the importance of continued research in this area to improve patient outcomes and advance cancer treatment options.

1. Source: Coherent Market Insights, Public sources, Desk research
2. We have leveraged AI tools to mine information and compile it