May 22, 2024

Amyotrophic Lateral Sclerosis Treatment Market is Poised to Grow Due to Advancements in Gene Therapy Technologies

ALS, also known as Lou Gehrig’s disease, is a progressive neurodegenerative disease that destroys motor neurons and impairs physical functions like walking, talking, swallowing, etc. over time. Currently, there are limited treatment options available for ALS that only focus on managing symptoms through medications like riluzole, edaravone and physical therapy. However, recent advancements in gene therapy and stem cell-based treatments are bringing new hope for better disease-modifying treatments in the future. The growing ALS prevalence along with rising awareness and heavy investments in R&D are driving the market growth.

The global amyotrophic lateral sclerosis treatment market is estimated to be valued at US$ 692.77 million in 2024 and is expected to exhibit a CAGR of 4.6% over the forecast period 2023 to 2030.

Key Takeaways:

Key players operating in the Amyotrophic Lateral Sclerosis (ALS) treatment market are Orion Corporation, Bausch Health Companies Inc., CYTOKINETICS, INC., Aquestive Therapeutics, Inc., Sanofi ,Covis Pharma, Sun Pharmaceuticals Industries Ltd, Mitsubishi Tanabe Pharma Corporation, BrainStorm Cell Limited, ViroMed Co., Ltd, Ionis Pharmaceuticals, Genervon Biopharmaceuticals, LLC, Biogen, Orphazyme A/S, Apotex Inc, Neuralstem, Inc., Implicit Bioscience, F. Hoffmann-La Roche Ltd, AB Science, ADVANZ PHARMA.

Research into advances like gene silencing, gene therapy, stem cell therapy and other novel targets offer promising opportunities for developing new and effective therapies. Biogen’s spinal muscular atrophy gene therapy Spinraza became the first FDA approved treatment to halt or reverse the progression of a genetic neuromuscular disorder in 2016, proving the potential of gene therapies.

Technological developments in CRISPR/Cas9 genome editing have allowed more precise manipulation of genes, accelerating research on developing gene replacement therapies for monogenic disorders like ALS. Advancements in biomarker identification are also helping select patient populations more likely to respond to new therapies in clinical trials.

Market Drivers:
The key drivers contributing to the growth of the global ALS treatment market include rising prevalence of ALS globally due to aging population and other risk factors, heavy investments in R&D, growing awareness regarding ALS and its treatment options, and development of novel drugs in pipeline for disease modification. The market is also being driven by ongoing clinical trials evaluating gene therapies, stem cell therapies and other non-traditional treatment approaches.

Challenges in Amyotrophic Lateral Sclerosis Treatment Market

The Amyotrophic Lateral Sclerosis Treatment market faces several challenges such as high costs involved in drug discovery and development, lack of understanding about the disease etiology, limited treatment options, and requirement of intensive post-diagnosis care. Drug development costs amount to billions and success rate is low due to various biological and technical barriers. Understanding the genetic and molecular causes of ALS remains a major challenge hindering development of effective therapies. Currently, there are only two marginally effective U.S FDA approved drugs for the treatment of ALS which provide very limited improvements. ALS patients require extensive physical, emotional and medical support post-diagnosis putting immense strain on caregivers and healthcare systems.

SWOT Analysis
Strength: Growing R&D investments from key players and governments to accelerate drug development. Rising awareness levels about ALS symptoms and available treatment options.
Weakness: Limited understanding of disease pathways makes drug discovery difficult. High treatment costs remain unaffordable for many patients.
Opportunity: Advancements in precision medicine and stem cell technologies offer potential for development of novel targeted therapies. Emerging markets in Asia Pacific expected to drive future growth.
Threats: Stringent regulatory requirements and clinical trial failures can delay drugs approvals. Shortage of skilled medical professionals to manage rising ALS patient base.

Geographical Regions
North America region currently dominates the Amyotrophic Lateral Sclerosis Treatment market accounting for over 40% of global market share in terms of value. This is attributed to presence of major players, strong healthcare infrastructure, growing research funding and rising incidence rates. Asia Pacific region has emerged as the fastest growing regional market stimulated by increasing medical tourism, rising living standards and growing focus of international players. China, India, South Korea and other Southeast Asian countries are anticipated to significantly boost the APAC Amyotrophic Lateral Sclerosis Treatment market during the forecast period.

The Amyotrophic Lateral Sclerosis Treatment market in Europe region is mainly concentrated in countries like Germany, United Kingdom and France majorly owing to wider acceptance of advanced treatment options. However, high prescription costs and economic issues in Southern European countries may restrain the regional market proliferation to some extent over coming years. Rest of world including areas of Latin America and Middle East & Africa holds relatively lower share currently but expected to provide numerous emerging opportunities through government support programs and expanding private healthcare sectors respectively for Amyotrophic Lateral Sclerosis Treatment market.

*Note:

  1. Source: Coherent Market Insights, Public sources, Desk research
  2. We have leveraged AI tools to mine information and compile it