April 20, 2024

Transitioning Kidney Rejection (Calcineurin Inhibitor Market) Is The Largest Segment Driving The Growth Of Calcineurin Inhibitor Market

Market Overview:

Calcineurin inhibitors help suppress the immune system and prevent rejection of transplanted kidneys. They work by inhibiting the action of calcineurin, which plays a key role in the immune response that leads to organ rejection.

Market Key Trends:

One of the key trends in the calcineurin inhibitor market is the development of extended-release formulations. This includes once-daily extended-release formulations of tacrolimus and cyclosporine that provide stable drug levels and improve patient compliance compared to the conventional formulations that require multiple daily doses. Transitioning kidney transplant recipients to extended-release formulations helps in better management of transplant rejection and also lowers healthcare costs associated with non-compliance to the regimen.

Calcineurin inhibitor drugs have seen increased adoption in recent years due to their efficacy and safety profile compared to other immunosuppressants. One key trend is the growing solid organ transplantation procedures globally. Since calcineurin inhibitors are commonly used post transplantation, their demand rises in tandem with transplant volume. Another factor fuelling their market is the increase in autoimmune disorders, for which these drugs are also prescribed. New formulations delivering calcineurin inhibitors in a targeted manner are expanding available treatment options as well.

SWOT Analysis

Strengths: Well-established drugs with proven efficacy records. Important therapeutic category with no substitutes available yet. Weaknesses: Associated side effects like nephrotoxicity and neurotoxicity. Narrow therapeutic index requiring careful dose management. Opportunities: Emerging biosimilar entrants providing cheaper alternatives. Geographical expansion into developing markets. Threats: Patent expiries opening path for generics. Strict regulations surrounding transplant drugs.

Key Takeaways

The Global Calcineurin Inhibitor Market Demand is expected to witness high growth, exhibiting CAGR of 10% over the forecast period, due to increasing solid organ transplantation globally. The market size for 2023 is estimated to be US$ 10.07 Bn.

Regionally, North America is projected to dominate the calcineurin inhibitor market owing to favorable reimbursement policies and accessibility of transplant procedures in the region. However, Asia Pacific is likely to emerge as the fastest growing market, driven by growing healthcare expenditure and increasing organ failure patient base.

Key players operating in the calcineurin inhibitor market are Novartis AG, Astellas Pharma Inc., LEO Pharma A/S, Allergan, Inc., Pfizer Inc., Sanofi SA, GlaxoSmithKline plc, Johnson & Johnson Services, Inc., Merck & Co., Inc., Roche Holding AG, Bristol Myers Squibb Company, AbbVie Inc., Eli Lilly and Company, Takeda Pharmaceutical Company Limited, Mylan N.V.


  1. Source: Coherent Market Insights, Public sources, Desk research
  2. We have leveraged AI tools to mine information and compile it