March 5, 2024
Pancreatic Cancer Therapeutics and Diagnostics

Advancements in Pancreatic Cancer Therapeutics: Current Strategies and Future Directions

Pancreatic cancer is one of the deadliest cancers with a low survival rate. However, recent advances in research are bringing hope for better diagnostics and therapeutics. This article discusses the current state and promising future of pancreatic cancer treatment and detection. Pancreatic cancer occurs when malignant cells form in the tissues of the pancreas. The pancreas is a gland located behind the stomach and in front of the spine. It releases enzymes that aid in digestion and hormones that help manage blood sugar levels. Pancreatic cancer is difficult to detect early as the pancreas is buried deep in the abdomen and symptoms often do not appear until the cancer has spread. It is also aggressively metastatic, spreading rapidly to lymph nodes and other organs. These reasons contribute to pancreatic cancer having a low survival rate compared to other cancer types.

Current Diagnostic Methods

The most common screening method for pancreatic cancer is abdominal imaging tests like CT scans, MRI scans, endoscopic ultrasound (EUS), and endoscopy. CT and MRI scans provide detailed images of the pancreas and surrounding tissues and organs to detect abnormalities. EUS allows doctors to examine the pancreas using a thin, lighted tube inserted through the mouth and can produce high-resolution images. However, masses must be at least 0.5 cm in size to be detected by most current imaging technologies. Blood tests that detect biomarkers like CA 19-9 are also used but have limited accuracy as levels can rise from other conditions too. More advanced diagnostic tools are needed to detect pancreatic cancer earlier when treatment has higher chances of success.

Promising Diagnostic Technologies

Researchers are exploring novel diagnostic technologies like liquid biopsies, multiparametric MRI, and artificial intelligence approaches. Liquid biopsy analyzes blood samples for traces of cancer DNA shed by tumors known as circulating tumor DNA or ctDNA. Studies show ctDNA may be detectable even in early stages and provide a non-invasive method for early cancer detection and monitoring. Multiparametric MRI combines different types of scans to detect tumors as small as a few millimeters by identifying subtle changes in tissue composition. Artificial intelligence is helping develop blood test panels and computer-aided analysis of medical images to greatly improve diagnostic accuracy. Such advanced diagnostics could revolutionize pancreatic cancer screening and prognosis.

Existing Treatment Options

The main pancreatic cancer treatment options are surgery, chemotherapy, radiation therapy, and palliative care depending on the stage. Surgical removal of tumors (pancreatectomy) offers the only potential cure but is only possible in about 20% of cases where tumors are localized and resectable. Chemotherapy uses drugs to destroy cancer cells and is given before or after surgery depending on the individual case. Chemotherapy may involve single drugs like gemcitabine or combinations of 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin. Radiation therapy uses high-energy rays to kill cancer cells and is used both before and after surgery. pancreatic cancer therapeutics and diagnostics focuses on pain relief and quality of life for advanced cases. However, overall survival has remained less than 10% due to resistance. New targeted therapies and immunotherapy are needed.

Promising Therapies in Development

Research into novel therapeutic strategies is bringing hope. Drug combinations that inhibit multiple cancer growth pathways show stronger responses than single agents. PARP inhibitors that block DNA repair in tumors with genetic BRCA mutations have shown benefits. Oncolytic virus therapies genetically engineer viruses to selectively infect and kill cancer cells. Angiogenesis inhibitors cut off the blood supply fueling tumors. Immunotherapies like checkpoint inhibitors that activate the immune system against cancer hold promise. T cell therapies customize a patient’s T cells to recognize and destroy pancreatic tumors. Nanoparticle drug delivery systems could enhance drugs’ effectiveness. FUS/HIFU uses focused ultrasound to heat and destroy tumor tissue. Clinical trials are exploring these approaches for safety, quality of life benefits and survival outcomes.

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1.      Source: Coherent Market Insights, Public sources, Desk research
2.      We have leveraged AI tools to mine information and compile it