by The Protein A Resin Market is estimated to be valued at US$ 656.9 Mn in 2023 and is expected to exhibit a CAGR of 8.5% over the forecast period 2023 to 2030, as highlighted in a new report published by Coherent Market Insights.
Market Overview:
Protein A resin is used widely for purification and separation of monoclonal antibodies (mAbs) and related recombinant proteins from cell culture media. It acts as an affinity ligand for immunoglobulins and selectively binds to the Fc region of antibodies. Protein A resin provides efficient and cost-effective purification with high yield and little process variability.
Market key trends:
One of the key trends driving the growth of protein A resin market is rising demand from biopharmaceutical industry. Protein A resin finds major application in downstream processing of monoclonal antibodies used in manufacturing of various biotherapeutic drugs. According to estimates, over 60% of all approved monoclonal antibody therapeutics are manufactured using protein A chromatography. With significant number of monoclonal antibodies in pipelines and over 800 monoclonal antibodies currently under clinical trials, the demand for protein A resin from biopharmaceutical companies is expected to grow considerably over the forecast period. Additionally, growing research and development activities for development of biosimilars will further propel the market growth of protein A resin during the forecast period.
Porter’s Analysis
Threat of new entrants: Low setup costs and low capital requirements restrain the threat of new entrants in the protein A resin market. However, existing large players enjoy economies of scale and brand loyalty that make entry difficult.
Bargaining power of buyers: The bargaining power of buyers is moderate as the protein A resin market is dominated by a few large established players who have strong expertise. These players can influence pricing; however, the unique properties of protein A resins provide some pricing power to suppliers.
Bargaining power of suppliers: The bargaining power of suppliers is low as protein A resins are manufactured using readily available raw materials like agarose and dextran. This reduces dependence on any single supplier.
Threat of new substitutes: No direct substitutes are available for protein A resins currently, but continuous developments are being made for alternate affinity chromatography resins to reduce production costs.
Competitive rivalry: High as major players focus on expanding their geographic presence and product portfolios through R&D and collaborations.
SWOT Analysis
Strength: Protein A resin occupies a unique position for antibody purification due to its high affinity and selectivity. It allows large-scale, cost-effective production of monoclonal antibodies.
Weakness: Production challenges and quality issues, high capital investment required for manufacturing facilities.
Opportunity: Rising monoclonal antibody therapeutics market, increasing biopharmaceutical R&D expenditure, and growing biologics manufacturing in developing regions.
Threats: Stringent regulatory norms, pricing pressures, and threat of substitutes.
Key Takeaways
The Global Protein A Resin Market Demand is expected to witness high growth, exhibiting CAGR of 8.5% over the forecast period, due to increasing demand for monoclonal antibody production. North America dominates the market currently due to presence of major biopharmaceutical players and CROs. Asia Pacific is projected to be the fastest growing region owing to increasing biosimilar manufacturing and expanding biopharma industry in China and India.
Regional analysis Asia Pacific region is expected to offer lucrative growth opportunities during the forecast period. This is attributed to favorable government policies supporting development of biosimilars and generics manufacturing in countries such as China, India, and South Korea. Rapid economic growth in these countries attracts major biopharmaceutical companies to establish manufacturing units and conduct clinical trials.
Key players operating in the protein A resin market are GE Healthcare, Thermo Fisher Scientific, Repligen, Tosoh Bioscience, EMD Millipore, Novasep, GenScript Biotech Corporation, Purolite Life Sciences, and Expedeon Ltd. Major players are focuses on developing novel resins through mergers & acquisitions, and collaborations with research institutes to strengthen their product portfolios.
*Note:
1. Source: Coherent Market Insights, Public sources, Desk research
2. We have leveraged AI tools to mine information and compile it
